Abstract：Insect phenoloxidase, presented as an inactive precursor prophenoloxidase (PPO) in hemolymph, catalyzes melanin formation, which is involved in wound healing, pathogen killing, reversible oxygen collection during insect respiration, and cuticle and eggshell formation. Mosquitoes possess 9 to 16 PPO members across different genera, a number that is more than that found in other dipteran insects....

Abstract：Treatment of tumor brain metastases remains challenging due to the ineffectiveness of drugs in crossing the blood–brain barrier (BBB). Here, we proposed a potential strategy to target and modulate the meningeal lymphatic system for immunotherapy of breast cancer brain metastases (BCBM) through peripheral administration. CT/fluorescence dual-modality imaging demonstrated that the phospholipid ...

Abstract:Electrochromic materials were discovered in the 1960s when scientists observed reversible changes between the light and dark states in WO3 thin films under different voltages. Since then, researchers have identified various electrochromic material systems, including transition metal oxides, polymer materials, and small molecules. However, the electrochromic phenomenon has rarely been observed ...

Abstract:Aqueous multivalent metal batteries have high theoretical capacities and are cost-effective; however, the low electrochemical reversibility caused by the notorious parasitic reactions of metal anodes hinders their practical application. In this study, an underpotential deposition (UPD) strategy for designing heterogeneous metal substrates to regulate the multivalent metal plating/stripping ...

Abstract: With the accelerating process of industrialization, heavy metal ions have become an increasingly serious threat to the ecological environment. Fluorescent covalent organic frameworks (FCOFs) are organic polymers, consisting of organic monomers linked by covalent bonds. In recent years, FCOFs have been applied in the field of heavy metal ion sensors owing to their unique pore structure, tunable ...

Abstract: Different from conventional multi-step synthesis methods for wrinkled polymer microspheres (WPMs), here we propose a facile one-step and one-pot synthesis strategy for WPMs employing monomer reactivity ratio difference to form linear-crosslinked-linear gradient structure from inside to outside of the microspheres, leading to wrinkled surface by uneven shrinkage of the crosslinked and linear ...

Abstract: Diquat (DQ), a contact herbicide extensively utilized in both agricultural and nonagricultural domains, exhibits a high correlation with neuronal disorders. Nevertheless, the toxicity and underlying mechanisms associated with exposure to environmental concentrations of DQ remain ambiguous. Here, we report dose-dependent cellular neurotoxicity of DQ in Caenorhabditis elegans. First, DQ significantly ...

Abstract: Background: Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial pneumonia with restrictive ventilation. Recently, the structural and functional defects of small airways have received attention in the early pathogenesis of IPF. This study aimed to elucidate the characteristics of small airway epithelial dysfunction in patients with IPF and explore novel therapeutic interventions ...

Abstract: Reversible electrodeposition and dissolution of manganese oxide (MnO2) represent an emerging electrochromic system. However, challenges such as “dead MnO2” formation, limited optical modulation across a narrow wavelength range, and difficulties in scaling up have significantly hindered the development of MnO2 reversible electrodeposition-based electrochromic windows. In this work, we introduced ...

Abstract: The factors influencing urban plant diversity in tropical cities remain underexplored. To address this gap, we conducted comprehensive field surveys and remote sensing analyses in Danzhou, Hainan Province, focusing specifically on urban functional units. Our study quantified the diversity of trees, shrubs, herbaceous plants, spontaneous species, and cultivated species, employing spatial autocorrelation ...