Abstract:Understanding disease-associated stem cell abnormality has major clinical implications for prevention and treatment of human disorders, as well as for regenerative medicine. Here we report a multifaceted study on airway epithelial stem cells in Tracheobronchopathia Osteochondroplastica (TO), an under-detected tracheobronchial disorder of unknown etiology and lack of specific treatment. Epithelial ...

Abstract:During the life history of the heterophyllous plant Ottelia cordata, it undergoes the submerged-leaf and the floating-leaf phases, with dramatic changes in their surrounding environments. In the present study, we investigated the changes in morphology, anatomy, and inorganic carbon (Ci) utilization strategies in heterophyllous leaves of O. cordata. The results showed that the floating leaf ...

Abstract:Benzophenones are widely supplemented in personal care products, but little is known about its neurodevelopmental toxicity. The previous epidemiological study discovered a negative correlation between maternal exposure to a benzophenone metabolite 4-hydroxybenzophenone (4HBP) and child's neurodevelopment, yet the causal relationship and detailed mechanism remain to be defined. Here, it is ...

Abstract:The defining trait of obligate anaerobes is that oxygen blocks their growth, yet the underlying mechanisms are unclear. A popular hypothesis was that these microorganisms failed to evolve defences to protect themselves from reactive oxygen species (ROS) such as superoxide and hydrogen peroxide, and that this failure is what prevents their expansion to oxic habitats. However, studies reveal ...

Abstract:The VosA-VelB hetero-dimeric complex plays a pivotal role in regulating development and secondary metabolism in Aspergillus nidulans. In this work, we characterize a new VosA/VelB activated gene called vadH, which is predicted to encode a 457-amino acid length protein containing four adjacent C2H2 zinc-finger domains. Mutational inactivation of vosA or velB led to reduced mRNA levels of vadH ...

Preface:The primary principle of designing a wireless communication system is to ensure the security of wireless data transmission. Different from cryptography schemes, the physical-layer secure (PLS) technology including channel coding and precoding takes full advantage of the physical characteristics (i.e., noise, fading, interference) of wireless channel to obtain a secure and efficient data transmission....

Abstract：Unmanned aerial vehicle (UAV)-assisted communication is a significant technology in 6G communication. In order to cope with the dynamic trajectory optimization problem of the air-ground network, the interaction between entities is modeled as a Markov game firstly. Then, the model-free multi-agent reinforcement learning (MARL) is adopted to optimize individual decision-making. This enables ...

Abstract：Cassava provides food and income for about billion people worldwide. However, Xanthomonas axonopodis pv. manihotis (Xam) causes cassava bacterial blight (CBB) and yield reduction worldwide in the tropics. Thus, genetic improvement between disease resistance and biomass should be finely balanced to avoid double-edged sword of some resistance genes. Ethylene response factors (ERFs) are widely ...

Abstract：The 4-methyl steranes serve as molecular fossils and are used for studying both eukaryotic evolution and geological history. The occurrence of 4α- methyl steranes in sediments has long been considered evidence of products of partial demethylation mediated by sterol methyl oxidases (SMOs), while 4β-methyl steranes are attributed entirely to diagenetic generation from 4α-methyl steroids ...

Abstract：Diverse algae of the red lineage possess chlorophyll a-binding proteins termed LHCR, comprising the PSI light-harvesting system, which represent an ancient antenna form that evolved in red algae and was acquired through secondary endosymbiosis. However, the function and regulation of LHCR complexes remain obscure. Here we describe isolation of a Nannochloropsis oceanica LHCR mutant, named ...