Nature Methods publishes HNU's optical tomography research
Nature Methods published the latest research results of Luo Qingming, academician of the Chinese Academy of Sciences and president of Hainan University, on high-definition imaging using line-illumination modulation microscopy on March 1.
Optical microscopes are an important tool for biomedical research at submicron resolution and how to use them to observe the complex structure of three-dimensional biological tissue is a universally acknowledged difficulty.
Illustration of Luo Qingming's thesis High-definition imaging using line-illumination modulation microscopy.
Luo's team proposed a new high-definition, high-throughput optical tomography method: line-illumination microscopy. It can record signals modulated by different intensities through multi-line detection at one time. A clear focal plane optical tomography image can be obtained via the simplest linear calculation to remove out-of-focus background signals.
Based on this, Luo's team further developed the high-definition fluorescent micro-optical sectioning tomography. It brings the definition of whole-brain optical imaging to a new level, while addressing the large-scale acquisition and analysis of whole-brain high-resolution datasets.
Luo's interview with Nature Methods.